Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

Abstract Major Depressive Disorder (MDD) and Generalized Anxiety (GAD) are highly debilitating often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral neurofunctional level. determination of disorder-specific may therefore promote neuro-mechanistic diagnostic specificity. In order to determine alterations in domain emotion-cognition interactions present study examined emotional context-specific inhibitory control treatment-naive MDD (n = 37) GAD (n = 35) patients healthy controls (n = 35). On level but not exhibited impaired irrespective context. neural level, MDD-specific attenuated recruitment inferior/medial parietal, posterior frontal, mid-cingulate regions during were found negative a stronger engagement left dorsolateral prefrontal cortex relative MDD. Overall findings from suggest disorder- major depression point depression-specific neuropathological marker.